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Postgrad Med ; 133(1): 20-27, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-759669

ABSTRACT

While COVID-19 has primarily been characterized by the respiratory impact of viral pneumonia, it affects every organ system and carries a high consequent risk of death in critically ill patients. Higher sequential organ failure assessment (SOFA) scores have been associated with increased mortality in patients critically ill patients with COVID-19. It is important that clinicians managing critically ill COVID-19 patients be aware of the multisystem impact of the disease so that care can be focused on the prevention of end-organ injuries to potentially improve clinical outcomes. We review the multisystem complications of COVID-19 and associated treatment strategies to improve the care of critically ill COVID-19 patients.


Subject(s)
COVID-19/physiopathology , COVID-19/mortality , Cardiovascular Diseases/physiopathology , Critical Illness , Cytokines/biosynthesis , Endocrine System Diseases/physiopathology , Gastrointestinal Diseases/physiopathology , Hematologic Diseases/physiopathology , Humans , Kidney Diseases/physiopathology , Musculoskeletal Diseases/physiopathology , Nervous System Diseases/physiopathology , Obesity/physiopathology , Organ Dysfunction Scores , Respiratory Tract Diseases/physiopathology , Risk Factors , SARS-CoV-2 , Skin Diseases/physiopathology , Systemic Inflammatory Response Syndrome/physiopathology
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